Early Diagnosis of Pulmonary Nodules

Inclusion Criteria: * Age ≥ 40 years * Smoking history: Never, Former, Current * Subject undergoing diagnostic evaluation for a lung nodule * Subject undergoing evaluation for a lung nodule by a pulmonologist, and/or by a thoracic surgeon * Baseline CT scan identifying lung nodule performed within 60 days of subject enrollment * Nodule(s) identified by CT scan previously not followed * Subject willing to provide informed consent for the collection of blood specimens Exclusion Criteria: * Nodule work-up at the time of enrollment eligibility indicates any prior attempted or completed diagnostic biopsy procedure, such as transthoracic needle aspiration, bronchoscopic biopsy or surgery * A prior CT scan is available that previously identifies the same lung nodule under consideration for study inclusion on the most current CT scan; AND the prior CT scan was performed more than 60 days before the current CT scan, irrespective of the candidate nodule's radiographic characterization such as size, density or appearance * Current diagnosis of any cancer * Prior diagnosis of any cancer within 2 years of lung nodule detection, except for non-melanoma skin cancer * Administration of blood products, e.g. packed red blood cells, fresh frozen plasma, or platelets, within 30 days of subject enrollment * History of human immunodeficiency virus (HIV) or Hepatitis C