Effects of Transcranial Direct Current Stimulation in Refractory Chronic Migraine and Medication-overuse Headache

Dr Armando Perrotta, MD, PhD30 enrolled

Overview

The purpose of the study is to evaluate the efficacy of the transcranial direct current stimulation of the primary motor cortex (M1) in patients affected by refractory chronic migraine (coded as 1.5.1 in the international headache classification 2nd edition, 2004) and medication-overuse headache (coded as 8.1) with migraine as primary headache.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Chronic Migraine Medication Overuse Headache

Interventions

Anodal transcranial direct current stimulationDEVICE

Sham transcranial direct current stimulationDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic MIgraine or Medication Overuse Headache according to the diagnostic criteria set out in the 2nd edition of the International Classification of Headache Disorders refractory to treatment according to the Refractory Headache Special Interest Section of the American Headache Society (Schulman et al., 2008) Exclusion Criteria: * Other primary or secondary headaches. * Any serious systemic or neurological disease or psychiatric disorder. * Pregnancy or breastfeeding * Previous or current use of other or similar devices for pain control * Heart conduction and rhythm disorders * Cranial surgery * Other pain conditions, accordingly with current guidelines

Outcomes

Primary Outcomes

Change in headache days per months

Time frame: at 30, 60 and 90 days after the treatment

Change in drugs intake per months

Time frame: at 30, 60 and 90 days after treatment

Secondary Outcomes

Change in mean pain intensity score per months

Time frame: at 30, 60 and 90 days after treatment

Data from ClinicalTrials.gov

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