Total Occlusion Study in Coronary Arteries - 5

Inclusion Criteria: * Male or females patients \> 18 years of age who has a clinically driven, planned PCI of the target CTO, in a major epicardial coronary artery, without planned revascularization of other coronary stenosis/stenoses in major epicardial segments. * Target CTO must be greater than or equal to 3 calendar months prior to Screening * Target CTO must meet protocol defined criteria for entry * Patient is receiving a course of optimal anti-ischemic medical therapy (at least 2 anti-anginal agents or the maximum tolerated anti-anginal therapy) Exclusion Criteria: * Documented chest radiation exposure \> 4.0 Gray within 8 weeks of Day 0 * Target vessel is not an occluded stent, saphenous vein graft * Patient had ACS \< 4 weeks from Screening, attributable to any coronary vessel * Patient has non-healed dissection plane extending to a point adjacent to the coronary lumen distal to the target CTO * Patient has a known or suspected target vessel perforation within 30 days of Day 0 * Angiographic exclusion criteria as defined in the protocol