Clinical Significance of 64-slice Multidetector Coronary CT Angiography to Evaluate the Prevalence and Severity of Coronary Artery Disease in Renal Transplant Recipients

Yonsei University93 enrolled

Overview

The aim of this study is to evaluate the clinical usefulness of 64-slice multidetector coronary CT angiography (MDCTA) in renal transplant recipients who had no previous coronary artery disease (CAD). Primary endpoint is to assess the prevalence and severity of coronary artery disease in patients post-transplant 6 to 12 months. CAD can be diagnosed noninvasively with similar accuracy of coronary angiography using MDCTA. Early detection and intervention of CAD may provide survival benefit in renal transplant recipients.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Kidney Transplant Recipient

Interventions

64-slice Multidetector coronary CT angiography

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. age ≥ 40 yrs 2. renal transplant recipient at post-transplant 6 to 12 months 3. stable graft renal function: CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) equation ≥45 mL/min/1.75m2 4. patients who had no previous CAD Exclusion Criteria: 1. unstable graft renal function 2. History of acute kidney injury within 3 months 3. Allergic history to contrast agent 4. Irregular heart beat 5. Multiorgan transplant recipients 6. Pregnancy 7. Patients who do not consent to this study

Outcomes

Primary Outcomes

prevalence of coronary artery disease

Time frame: at post-transplant 6 to 12 months.

Secondary Outcomes

severity of coronary artery disease

Time frame: at post-transplant 6 to 12 months