Norursodeoxycholic Acid in the Treatment of Primary Sclerosing Cholangitis

Inclusion Criteria: 1. Signed Informed Consent 2. Verified diagnosis of PSC 3. PSC patients with or without IBD 4. Women of childbearing potential have to apply during the entire duration of the study a highly effective method of birth control. Exclusion Criteria: 1. History or presence of other concomitant liver diseases 2. Treatment with UDCA within 8 weeks prior to baseline visit. 3. Child B/C liver cirrhosis 4. Total bilirubin \> 3.0 mg/dl at screening or baseline. 5. Any relevant systemic disease 6. TSH\>ULN at screening 7. any severe concomitant cardiovascular, renal, endocrine, or psychiatric disorder 8. Any active malignant disease 9. Known intolerance/hypersensitivity to study drug 10. Existing or intended pregnancy of brest feeding 11. Simultaneous participation in another clinical trial