Clinical Evaluation of the OrthoPAT Advance System

Inclusion Criteria: * Male or female over the age of 18 years * Subject is scheduled for a total knee/hip replacement/ revision or a hysterectomy. * Subjects determined eligible per site standard of care for use of intra- and post-operative use of cell salvage device Exclusion Criteria: For subjects where product is transfused * Subject is undergoing a trauma procedure where there is a possibility of contamination from an open wound. * Patient is diagnosed with sepsis. * Patient is diagnosed with sickle-cell anemia. * Malignant cells may be mixed with blood salvaged from the surgical field. * Prostatic or amniotic fluid is mixed with blood salvaged from the surgical field. * Blood salvaged from the surgical field may be contaminated from an active infection at wound/drain site. * Blood salvaged from the surgical field contains topical hemostatic agents, anti-bacterial agents, or wound irrigants not intended for parenteral use. For all subjects: * Subject is undergoing a procedure which involves high, rapid blood loss such as liver transplants, certain cardiovascular procedures, and trauma procedures where blood loss is high (per Investigators judgment). * Any procedure terminated prior to completion by subject request, operator decision or error, or device error. * Any subject with which at least 200mL of filtered blood or 1 full disc is not available for processing and data collection within the study.