Fluid Balance During Closure of Atrial Septal Defect

Oslo University Hospital41 enrolled

Overview

This project will evaluate fluid balance and oedema formation in children with the same congenital heart disease (Atrial Septal Defect) who will either go through heart surgery with the use of Cardio Pulmonary Bypass and hypothermia or through interventional catheterization. The investigators will measure interstitial colloid osmotic pressure, distribution of proteins and cytokines. The study hypothesis is that "Oedema developed during heart surgery is caused by reduced colloid osmotic pressure gradient through the capillary membrane".

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Defects,Congenital Heart Septal Defects, Atrial

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 10 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The diagnosis of Atrial Septal Defect scheduled for closure * Informed consent Exclusion Criteria: * Renal failure, * liver failure, * coexisting cardiac malformations

Locations (1)

Oslo University Hospital

Oslo, Norway

Outcomes

Primary Outcomes

Interstitial colloid osmotic pressure

Time frame: During surgery or interventional closure

Data from ClinicalTrials.gov

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