The Effect of Stevia Rebaudiana Extracts on Different Variables Related to Caries: an in Vitro and in Vivo Evaluation.

Università degli Studi di Sassari20 enrolled

Overview

The aim of the present investigation was to evaluate the effect of stevioside and rebaudioside on several variables related to caries development. Two approaches were performed: an in vitro evaluation of the growth of a culture of mutans streptococci and in vivo randomized study on the effect of a single rinse containing stevioside and rebaudioside on plaque-pH.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Dental Caries

Interventions

Effect of Stevioside and Rebaudioside on plaque pHDIETARY_SUPPLEMENT

After measuring baseline plaque pH, the subjects rinsed for 1 minute with the sucrose solution. Plaque pH was then measured at 5, 10, 15, 30, 45 and 60 min after the mouth rinse.

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: good general health, normal salivary secretion rate, normal buffer capacity Exclusion Criteria: systemic diseases, salivary secretion reduction, reduced buffer capacity

Outcomes

Primary Outcomes

Plaque-pH modification

Plaque pH was measured at baseline and 5, 10, 15, 30, 45 and 60 minutes after each mouth rinse

Time frame: 5, 10, 15, 30, 45, 60 minutes

Data from ClinicalTrials.gov

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