Treatment of prednisone plus cyclophosphamide may be superior to treatment of prednisone alone in patients with advanced-stage IgA nephropathy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
135
1. prednisone plus cyclophosphamide: prednisone(0.5mg/kg/day\*6 months) plus cyclophosphamide(1g intravenous use,per 1 month\*6months); 2. supportive care,including ACE-I or ARBs and blood pressure control
1. prednisone alone: prednisone(0.5mg/kg/day\*6 months); 2. supportive care,including ACE-I or ARBs and blood pressure control
Guangdong General Hospital
Guangzhou, Guangdong, China
the changes of kidney function or death
the changes of estimated glomerular filtration rate (eGFR) or a combination of reaching end-stage renal disease (ESRD) or doubling of serum Creatinine or death
Time frame: 3,6 ,12, 24 and 36 months or more after treatment
the changes of proteinuria
Time frame: 3,6 ,12, 24 and 36 months or more after treatment
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