Economic Impact of Switching From Metoprolol to Nebivolol for Hypertension Treatment

Forest Laboratories3,000 enrolled

Overview

This is a retrospective data analysis of patients with high blood pressure (hypertension) who took metoprolol for a minimum of 6 months who then switched to taking nebivolol for a minimum of 6 month to treat hypertension. These patients will be identified from a large medical claims database. This study tests the hypothesis (alternative, higher or lower) that average patient monthly health care administrative cost changes after switching from metoprolol to nebivolol.

Study Type

OBSERVATIONAL

Enrollment

3,000

Conditions

Hypertension

Interventions

MetoprololDRUG

Metoprolol, oral administration

NebivololDRUG

Nebivolol, oral administration

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Be at least 18 years old at initiation of metoprolol (or first date on metoprolol treatment between 2007 and 2011) * Had one or more inpatient or outpatient claims with a primary or non-primary diagnosis of hypertension (ICD-9-CM 401.xx-405.xx) * Received nebivolol treatment continuously (defined as supply gap \<30 days) for at least 6 months after initiation * Received metoprolol treatment continuously for at least 6 months prior to switching to (initiation of) nebivolol (defined as metoprolol was discontinued whereas a prescription for nebivolol was filled) * Had at least 12 months of continuous enrollment (as verified using enrollment file): 6 month prior to nebivolol initiation and 6 months following nebivolol initiation.

Locations (1)

Forest Investigative Site 0

Jersey City, New Jersey, United States

Outcomes

Primary Outcomes

Patient monthly health care cost

The average per patient monthly health care cost for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol

Time frame: 6 months

Secondary Outcomes

Number of monthly out-patient visits

Estimate the average per patient monthly number of out-patient visits for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol.

Time frame: 6 months

Monthly Emergency Room visits per patient

Estimate of the average monthly number of Emergency Room (ER) visits per patient for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol.

Time frame: 6 months

Monthly hospitalizations per patient

Estimate of the average monthly number of hospitalizations per patient for the pre-specified hypertensive target study population during the 6 months before and after switching from metoprolol to nebivolol.

Time frame: 6 months

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.