Antipsychotic Discontinuation in High-risk Subjects

Seoul National University Hospital

Overview

* Would be there any difference in dopamine synthesis between remitted clinical high risk subjects for psychosis and healthy control? * What would happen to dopamine synthesis after antipsychotic discontinuation in clinical high risk subjects for psychosis? * What about the dopamine synthesis in recurred clinical high risk subjects for psychosis after the discontinuation?

After the antipsychotic medication discontinuation, we are going to assess the changes of the biological markers

Study Type

OBSERVATIONAL

Conditions

Schizophrenia

Eligibility

Sex: ALLMin age: 16 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed as a clinical High Risk * Treated with antipsychotic drugs * PSP1-5 (from SIPS criteria) \<3 (severity index)for more than 6 months * Had not experienced a symptomatic relapse in the 6 months Exclusion Criteria: * Significant abnormality in laboratory tests * History of head trauma

Locations (1)

Seoul National University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Presynaptic dopamine synthesis in the striatum

measured with \[18F\]DOPA positron emission tomography

Time frame: baseline

Data from ClinicalTrials.gov

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