Heliox in Preterm Infants With Respiratory Distress Syndrome

Third Military Medical University36 enrolled

Overview

Heliox can lower respiratory resistance, improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.

Heliox can improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation. Heliox has not been widely used. More studies on the effects and safety of Heliox in addition to NIPPV and mechanical ventilation should be tried.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Respiratory Distress Syndrome

Interventions

helioxOTHER

heliox or oxygen is used in the two groups respectively

Eligibility

Sex: ALLMin age: 28 WeeksMax age: 37 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * Gestational age more than 28 weeks and less than 32 weeks * Diagnosed as respiratory distress syndrome * Need to use NIPPV ventilation * No congenital diseases or hereditary diseases * With an informed consent form Exclusion Criteria: * With congenital diseases or hereditary diseases * Intubated in the delivery room * Need surgery

Locations (2)

Daping Hospital

China, Chongqing Municipality, China

Daping Hospital and Research Institute of Surgery

Chongqing, China

Outcomes

Primary Outcomes

length of ventilation and risk of mechanical ventilation

The primary outcome is the length of ventilation and risk of mechanical ventilation of participants.

Time frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Secondary Outcomes

Transcutaneous blood gas analysis，ventilator parameters and lung inflammation cytokines

Time frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Data from ClinicalTrials.gov

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