Three Anaesthesic Method in Electroconvulsive Theraphy

Inonu University39 enrolled

Overview

To compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane in ECT.

The purpose of this study is to compare the effectiveness of three different anesthetic regimens (propofol, remifentanil-propofol and sevoflurane) with respect to seizure duration, postictal suppression index, early and midictal amplitude, hemodynamic variables and recovery profiles in ECT.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Anesthesia

Interventions

PropofolDRUG

1 mg/kg propofol IV (over 15 sec) during anesthesia induction

Remifentanil and propofolDRUG

1 µg/kg IV (over 60 sec)remifentanil and 0.5 mg/kg propofol IV (over 15 sec)during anesthesia induction

SevofluraneDRUG

Sevoflurane was started at 6% for induction and continued at 1% until the electrical stimulus was delivered

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Upremedicated ASA I-II (American Society of Anesthesiologists's physical status) patients, * Patients scheduled for six ECT sessions for a variety of psychiatric conditions (major depression, schizophrenia) Exclusion Criteria: * Involuntary patient status * Patients with known or self-declared needle or mask phobia * Pregnancy * Asthma * Cerebrovascular disease, * History of myocardial infarction in the previous 6 months, * Atrial fibrillation or flutter,heart block, * A known or family history of reactions to the study drugs.

Locations (1)

Turgut Ozal Medical Center

Malatya, Turkey (Türkiye)

Outcomes

Primary Outcomes

Seizure duration

After anesthesia induction patients were administered electrical stimulation and seizure duration were measured.

Time frame: The patients were observed about seizure up to ten minutes after electrical stimulation

Secondary Outcomes

postictal suppression index

After anesthesia induction, patients were administered electrical stimulation. Then, postictal suppression index, a parameter that shows seizure quality, was determined from seizure records.

Time frame: completing seizure in one hour

Recovery parameters (spontaneous breathing, eye opening, and obeying of verbal commands)

The time from the end of succinylcholine administration to the recovery of spontaneous breathing, eye opening, and obeying of verbal commands were recorded.

Time frame: after seizure in one hour in operation room.

Hemodynamic variables

During perioperative period: Before administration of the study medications (t0), and at 1 (t1), 3 (t2), and 10 (t3) minutes after the seizure ended.

Time frame: Before administration of the study medications (t0), and at 1 (t1), 3 (t2), and 10 (t3) minutes after the seizure ended.

Data from ClinicalTrials.gov

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