Thirteen hospitals in China will participate in the study, which aims to provide data on serum bilirubin levels in the first 168 hr after birth in term and late-preterm neonates, and estimate the incidence of severe neonatal hyperbilirubinemia and the underlying causes. We hypothesize that the study can be value in identifying and implementing strategies for risk reduction.
Neonatal hyperbilirubinemia resulting in clinical jaundice is a common problem among infants, particularly during the first weeks of life. Information about the incidence and risk factors of neonatal jaundice is not available from China where is one of the highest countries of the incidence of severe neonatal hyperbilirubinemia.
Study Type
OBSERVATIONAL
Enrollment
13,157
The decision to use phototherapy conformed to the hour-specific threshold value for phototherapy presented by the American Academy of Pediatrics guidelines and was not at the discretion of the investigators.
Guangdong Maternal and Children's Hospital, Guangzhou Medical College
Guangzhou, Guangdong, China
Guangxi Maternal and Child Health Hospital
Liuchow, Guangxi, China
The incidence of severe neonatal hyperbilirubinemia
Significant hyperbilirubinemia was defined as any TSB level that exceeded the hour-specific threshold value for phototherapy, according to the guidelines presented by the American Academy of Pediatrics.
Time frame: At the 28 days after birth
Number of participants with risk factors associated with severe neonatal hyperbilirubinemia
The risk factors recognized to be associated with significant hyperbilirubinemia in newborns have included gestational age, weight for Gestational Age, delivery mode, gender, previous infant had phototherapy, bruising/cephalahematoma, feeding mode, excessive body weight loss, and early discharge, et al.
Time frame: At the 28 days after birth
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Guiyang Maternal and Child Health Hospital
Guiyang, Guizhou, China
The First Hospital of Harbin Medical University
Harbin, Heilongjiang, China
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China
Inner Mongolia Maternal and Child Health Care Hospital
Hohhot, Inner Mongolia, China
Nanjing Maternity and Child Health Care Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
Jinlin Provincial Maternal and Child Health Hospital
Changchun, Jilin, China
Shaanxi Provincial Maternal and Child Health Hospital
Taiyuan, Shaanxi, China
Sichuan Provincial People's Hospital
Chengdu, Sichuan, China
...and 4 more locations