β-blockers (BBs) with different pharmacological properties may have heterogeneous effects on sympathetic nervous activity (SNA) and central aortic pressure (CAP), which are independent cardiovascular factors for hypertension. Hence, we analyzed the effects of bisoprolol and atenolol on SNA and CAP in hypertensive patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
109
State Key Laboratory of Medical Genomics, Shanghai Key Laboratory of Hypertension and Department of Hypertension, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
baroreflex sensitivity
After 2-week maintenance treatment when the RHR was ≤65 bpm or at 8-week final visit
Time frame: 4~8 weeks
central aortic pressure
After 2-week maintenance treatment when the RHR was ≤65 bpm or at 8-week final visit
Time frame: 4~8 weeks
heart rate variability
After 2-week maintenance treatment when the RHR was ≤65 bpm or at 8-week final visit
Time frame: 4~8 weeks
peripheral blood pressure
After 2-week maintenance treatment when the RHR was ≤65 bpm or at 8-week final visit
Time frame: 4-8 weeks
Number of Participants with Adverse Events as a Measure of Safety and Tolerability
After 2-week maintenance treatment when the RHR was ≤65 bpm or at 8-week final visit
Time frame: 4-8 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.