High Protein Weight Loss Diet, High Sensitivity C-Reactive Protein and Cardiovascular Risks Among Obese Women

Isfahan University of Medical Sciences63 enrolled

Overview

The investigators aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.

Background: Studies regarding the effects of high protein (HP) diet on cardiovascular (CVD) risk factors have reported contradictory results. Objective: In present study, we aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women. Design: In this randomized controlled trial, we recruited 60 overweight and obese women, aged 20-65 years into HP or control energy restricted diets for three months (protein, carbohydrate, fat: 25%, 45%, 30% vs. 15%, 55%, 30%, respectively). Total protein amount, divided to animal and plant sources in 50%-50% and animal sources distributed (half/half) between meats and dairy products. Fasting blood samples, hs-CRP, lipid profile, systolic and diastolic blood pressure and anthropometric measurements were measured based on the standard guidelines.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

SINGLE

Enrollment

Conditions

Body Mass Index Quantitative Trait Locus 8 Disorder Tangier Disease

Interventions

nutrition interventionOTHER

high protein diet

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * women aged between 20-65 years * BMI \> 25 kg/m2 * were no smoker * no history of renal, liver, metabolic diseases or type 1 or 2 diabetes Exclusion Criteria: * had gastrointestinal, respiratory, cardiovascular, metabolic, liver and renal -diseases * had macroalbuminuria * were pregnancy or lactating

Outcomes

Primary Outcomes

the amount of weight reduction in two dietary groups

weight reduction (kg)

Time frame: 3 months

Secondary Outcomes

LDL-C (mg/dl

measurement of LDL-C (mg/dl), HDL-C (mg/dl), total cholesterol (mg/dl), fasting blood glucose (mg/dl), systolic and diastolic blood pressure (mmHg), c reactive protein by the measurement of blood samples.

Time frame: 3 months

HDL-C (mg/dl)

Time frame: 3 months

total cholesterol (mg/dl)

Time frame: 3 months

fasting blood glucose(mg/dl)

Time frame: 3 months

blood pressure (mmHg)

Time frame: 3 months

C-reactive protein (mc/dl)

Time frame: 3 months

Data from ClinicalTrials.gov

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