Oxidative stress occurs as a result of increased activity of free radical-producing enzymes, decreased activity of free radical-removing enzymes, and insufficient levels of antioxidants. The most sensitive molecules to oxidation are lipids. Loss of cell membrane elasticity, increased cell fragility, and a shortened cellular life span results from oxidation of cell membrane lipids.
Free oxygen radicals may have an effect on the structural and functional damage of platelets and plays a role in pathogenesis of thrombocytopenia in both, acute and chronic ITP. Selenium is an essential mineral found in small amounts in the body. It works as an antioxidant, especially when combined with other antioxidants as vitamin E , A and C. Antioxidants neutralize free radicals and may reduce or even help prevent some of the damage they cause. aim of this study is to assess oxidant and antioxidant systems initially in patients with acute and chronic immune thrombocytopenia (ITP) and 6 months later.Another aim of the study is to evaluate effect of antioxidant therapy on bleeding score, platelet count and antioxidant status during 6 months follow-up.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
effect of antioxidant on disease outcome
drugs will be selected according to ASH,2011 guidelines
hematology clinic ,pediatrics hospital, Ain Shams University hospital Cairo, Egypt
Cairo, Egypt
oxidant status in ITP
oxidant and antioxidant systems initially in patients with acute and chronic immune thrombocytopenia (ITP)
Time frame: 6 month
antioxidant therapy
antioxidant therapy on bleeding score, platelet count and antioxidant status
Time frame: 6 months
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