The study objective is to evaluate the efficacy of paclitaxel-bevacizumab comparing to docetaxel. Docetaxel is a standard treatment of 2nd or 3rd line in lung cancer. It was validated by numerous clinical trials but sometimes toxicities are difficult to manage. Bevacizumab is an antiangiogenic treatment which was validated by numerous clinical trials in association with platinum in first ligne. Different clinical and preclinical data suggest that there could exist a synergy between paclitaxel and bevacizumab. This association is already used in metastatic breast cancer, it permits almost to double the response rate and progression free survival. In lung cancer, the association was evaluated by two retrospective studies which demonstrated a benefit with a favourable safety profile.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
166
75 mg/m² IV on day one of 21 days cycle Number of Cycles: until progression or unacceptable toxicity develops.
90 mg/m² IV on day 1, 8 and 15 of 28 days cycle Number of Cycles: until progression or unacceptable toxicity develops.
10 mg/kg IV on day 1 and 15 of 28 days cycle Number of Cycles: until progression or unacceptable toxicity develops.
Amiens - CHU
Amiens, France
Centre Hospitalier
Annemasse, France
Hôpital Privé d'Antony
Antony, France
Avignon - Institut Sainte-Catherine
Avignon, France
CH de la Côte Basque
Bayonne, France
Béziers - CH
Béziers, France
Progression free survival
Time between inclusion and progression
Time frame: about 4 months
Response Rate
Time frame: At 8 weeks
Overall survival
Time between inclusion and death
Time frame: about 8 months
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Bordeaux - Polyclinique Nord
Bordeaux, France
Caen - Centre François Baclesse
Caen, France
Caen - CHU Côte de Nacre
Caen, France
Castelnau Le Lez - Clinique
Castelnau, France
...and 45 more locations