Taste Acuity and Caloric Intake After Acute Morphine Administration

Johns Hopkins University36 enrolled

Overview

This study will investigate the effects of acute morphine administration on taste acuity and how much a person eats. It is hypothesized that there will be a dose dependent decrease in taste acuity and dose dependent increase in food intake associated with acute morphine administration. Knowledge from this study will impact the future of feeding behavior and obesity research in the general population. Results will also promote exploration of the long-term effect of opioid abuse on taste acuity and feeding behavior in substance abusing populations.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Taste Sweet Taste Salty Feeding Behavior

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy adult male and female volunteers * Ages of 18 to 65 Exclusion Criteria: * History of drug dependence (including opioid use disorders) * History of taste dysfunction * Significant medical or Axis I psychiatric disorder * Any trauma or surgical procedures to the head or neck region * Medication or illicit drug more than 4 out of the last 30 days. * Pregnancy * Abnormal electrocardiogram findings * Negative rating of greater than 40% of the foods available for consumption

Outcomes

Primary Outcomes

Taste

The primary outcome variable will be the taste acuity profile, which includes the taste detection threshold, recognition threshold, magnitude estimation, and hedonic response.

Time frame: 3 hours after dose administration

Secondary Outcomes

Calories

The secondary outcome measure will be the amount of calories consumed over a 2 hours period following the drug administration.

Time frame: 6 hours after dose administration