No treatments have been shown to slow prostate cancer progression after radical prostatectomy. We hypothesize that a carbohydrate restricted diet will slow prostate cancer growth. A total of 60 men with a rising prostate-specific antigen (PSA) after failed primary treatment will be recruited and randomized to either a low-carbohydrate diet (\<20 grams carbohydrates/day) or a no-diet control (standard of care) for 6 months. The primary outcome is PSA doubling time.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
83
The Low carbohydrate diet intervention recommends patients to limit carbohydrate intake to less than 20 gram per day.
Cedars-Sinai Medical Center
Los Angeles, California, United States
Duke University Medical Center
Durham, North Carolina, United States
Durham VA Medical Center
Durham, North Carolina, United States
PSA doubling time (change in PSA over time)
PSA doubling time will be estimated from PSA measured at baseline, 3 and 6 months post randomization.
Time frame: Baseline, 3 and 6 months
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