[124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection

Inclusion Criteria: 1. Male and female patients \>/= 18 years on the day of signing consent. 2. A diagnosis of diabetes mellitus, type I or II, as evidenced either by HbA1c\>6.5% or receipt of antidiabetic medication at time of enrollment. 3. Ability to provide informed consent 4. An inframalleolar ulcer of perfusion, extent/size, depth/tissue loss, infection and sensation (PEDIS) grade 2 or 3. At the discretion of the Investigator, patients with PEDIS grade 4 infections may be included if they are sufficiently stable. 5. For females of childbearing potential, a negative urine pregnancy test on the day of dosing. 6. For females of childbearing potential, a willingness to use 2 methods of contraception for 30 days after receiving \[124I\]FIAU. 7. Ability to return for all study assessments. 8. Clinically euthyroid, or on stable thyroid replacement therapy. Exclusion Criteria: 1. Patients who ar unable to comply with study requirements. 2. Indication, in the opinion of the principal Investigator for urgent surgery that would preclude the time needed for PET-CT scanning, or clinical instability that precludes PET-CT scanning. 3. History of an inherited mitochondrial disorder (eg. Leber's hereditary neuropathy, neuropathy, ataxia, retinitis pigmentosa and ptosis \[NARP\], myoneurogenic gastrointestinal encephalopathy \[MNGIE\], myocolonic epilepsy with ragged red fibers \[MERFF\] and mitochondrial myopathy, encephalomyopathy, lactic acidosis and stroke-like syndrome \[MELAS\]) 4. Alanine aminotransferase (ALT)\>5x Upper Limit of Normal (ULN) OR aspartate aminotransferase (AST) \>5x ULN. 5. Body mass that exceeds the rating of the CT table. 6. Hypersensitivity to iodine. 7. Pregnant or breast-feeding. 8. Any condition that would put the patient at unreasonable risk in the opinion of the Investigator.