Cerebral Dysfunction in Chronic ITPwith High Risk of Serious Bleeding Excluding Intracranial Hemorrhage.

Ain Shams University100 enrolled

Overview

Intracranial hemorrhage despite being rare, several chronic ITP patients experience moderate to severe behavioral problems including learning difficulties, memory affection .These changes could be due to the presence of minute capillary dysfunction

* First identify the presence of cognitive, behavioral and/or minimal neurological deficit in patients with chronic ITP and correlate these changes with radiological evidence of minimal CNS bleeding. * Second investigate the correlation between these behavioral and/or minimal neurological deficits and duration, site and severity of bleeding (a total of 200 patient of persistently low platelet count \< 20x 10 9 for at least more than one month duration). * The aim is to assess the behavioral changes in chronic ITP patients, and to assess the possible relation of such changes to duration and recurrence of very low platelet count as well as pattern of bleeding excluding frank intracranial hemorrhage.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Chronic Thrombocytopenia

Interventions

IQ assessment and visual- motor assessmentOTHER

Psychological examination and evaluation for both groups to diagnose those with behavioral and /or cognitive dysfunction.

EEG,brain imagingOTHER

For patients with cognitive or behavioral deficit, MRI brain and quantitative EEG will be done to identify any CNS abnormality.

Eligibility

Sex: ALLMin age: 4 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Chronic ITP patients with persistent platelet count \< 20 x 109/L for a period more than one month. 2. Chronic ITP with more than one attack of wet purpura and OR internal bleeding. Exclusion Criteria: 1. Patients' with platelet count persistently more than 40 x 109/L. 2. Past history of intracranial hemorrhage. 3. Past history of known neurological or psychological deficit diagnosed before onset of ITP diagnosis

Locations (1)

hematology clinic, pediatric hospital, Ain Shams University

Cairo, Egypt

Outcomes

Primary Outcomes

cognitive, behavioral and/or minimal neurological deficit in patients with chronic ITP

cognitive, behavioral and/or minimal neurological deficit in patients with chronic ITP and correlate these changes with radiological evidence of minimal CNS bleeding.

Time frame: 6 month

Secondary Outcomes

duration, site and severity of bleeding effect of duration, site and severity of bleeding

behavioral and/or minimal neurological deficits and duration, site and severity of bleeding

Time frame: 6 months

Central Contacts

yasmine I Elhenawy, lecturer

CONTACT

0104084038 dr_yasmi@yahoo.com

Data from ClinicalTrials.gov

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