Signal Transfer of Atrial Fibrillation Data to Guide Human Treatment

Inclusion Criteria: * Age 18 or above, or above legal age and willing and capable of giving informed consent specific to national law * Scheduled for a clinically indicated cardiac ablation for the treatment of persistent atrial fibrillation * Able to meet study requirements for follow-up visit Exclusion Criteria: * Permanent leads or presence of prosthetic or severely stenotic tricuspid or mitral valves * Active systemic infection or sepsis * Echocardiographically confirmed presence of thrombus * Atrial thrombus, myxoma, inter-atrial baffle patch or occluder device for those subjects in whom a transseptal approach is required * Subjects who cannot be anticoagulated or infused with heparinized saline * Heparin induced thrombocytopenia * Hemodynamic instability or shock * Atrial anatomy contradictory to catheter labeling or size indices * EF \< 35% * Subjects with an active heart failure decompensation