The purpose of this study is to identify the effect of prophylactic entecavir in HBsAg Negative/HBcAb Positive/hepatitis B virus DNA Negative patients with lymphoma.
The purpose of this study is to identify the effect of prophylactic entecavir in HBsAg Negative/HBcAb Positive/hepatitis B virus DNA Negative patients with lymphoma are randomized into entecavir prophylaxis group or observation group. In entecavir prophylaxis group, entecavir 0.5 mg/day orally is initiate on day 1 of the first course of antitumor therapy, and will be continued until at least 6 months after completion of antitumor therapy. In observation group, entecavir 0.5mg daily will be prescribed for patients with hepatitis B virus reactivation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
190
Entecavir 0.5mg daily from day 1 of antitumor therapy to at least 6 months after completing antitumor therapy
Entecavir 0.5mg daily will be prescribed for patients with hepatitis B virus reactivation.
Peking University Cancer Hospital & Institute
Beijing, Beijing Municipality, China
RECRUITING307 Hospital of the Chinese People's Liberation Army
Beijing, Beijing Municipality, China
the incidence of hepatitis B virus reactivation and hepatitis B virus reactivation related hepatitis
Time frame: from the beginning of anti-tumor therapy to 18 months after the last cycle of anti-tumor therapy
the incidence of hepatitis B virus maintained response, the incidence of hepatitis B virus sustained response, the incidence of hepatitis B virus relapse and hepatitis B virus relapse related hepatitis
Time frame: from the beginning of anti-tumor therapy to 18 months after the last cycle of anti-tumor therapy
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309 Hospital of the Chinese People's Liberation Army
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