Generation 100: Blood Volume and Cardiac Function in Healthy Aging

Norwegian University of Science and Technology25 enrolled

Overview

Hypothesis: Exercise will reduce morbidity and mortality rates in an elderly population. The extent of reduction will be intensity dependent. As part of the "Generation 100" study, this sub-study project will investigate the effect of exercise on blood volume, cardiopulmonary health and heart function in healthy aging. Objective is to determine the acute effect of one endurance training session on blood volume in healthy elderly. The working hypothesis is that one interval training session increases total blood volume by 10% in healthy elderly, and that there will be no change after moderate continuous training.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Ageing

Interventions

high intensity interval training

Eligibility

Sex: ALLMin age: 70 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * ability to walk at least 1km, * born in 1938,1939,1940,1941 or 1942 * Sufficiently good health to be able to take part in the study, as determined by the researchers Exclusion Criteria: * Illness or disability that precludes exercise or hinders completion of the study * Uncontrolled hypertension * Symptomatic valve disease, hyper tropic cardio-myopathy or unstable angina * Active cancer * Test results indicating that study participation is unsafe * Inclusion in other studies conflicting with participation in this one

Outcomes

Primary Outcomes

total blood volume

carbon monoxide-rebreathing spirometry (Bayreuth, Germany)

Time frame: 24 hours

Secondary Outcomes

hemoglobin volume