The Effect of Probiotics on Exacerbation of Inflammatory Bowel Disease Exacerbation (Crohn's Disease)

The Baruch Padeh Medical Center, Poriya60 enrolled

Overview

Inflammatory Bowel Disease (IBD) is an immune mediated chronic intestinal condition. It includes ulcerative colitis (UC) and Crohn's disease(CD). probiotics have been shown to be effective in varried clinical conditions ranging fron infantile diarrhea, necrotizing enterocolitis,helicobacter pylori infections, etc.

This is a prospective study that will enroll 50 patients with Crohn's disease.Each patient will get the study medication for 6 weeks and will be evaluated twice- before enrollment and after 6 weeks of treatment.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Crohn's Disease

Interventions

ProbioticDRUG

Clinical evaluation according to the Crohn's activity scale

PlaceboDRUG

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with Crohns' disease who are stable or have mild acute exacerbations that do not necessitate treatment with systemic corticosteroids Exclusion Criteria: * pregnant women, under 18 years or over 60 years, * patients with known ulcerative colitis, * patients with any cancer, * patients with heart failure

Locations (1)

Baruch Padeh Medical Center

Tiberias, Lower Galilee, Israel

Outcomes

Primary Outcomes

endothelial stem cells

to study the ability to create endothelial progenitor stem cells following probiotic management compared to placebo group

Time frame: one year

Data from ClinicalTrials.gov

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