Recombinant Human IL-18 and Ofatumumab After PBSCT for Lymphoma

Inclusion Criteria: * Patients who have undergone high-dose therapy and autologous PBSCT for treatment of CD20+ lymphoma. * Patients must be between 2-6 months post-transplantation at the time of study registration. * Patients must have at least stable disease (no overt progressive disease) at the time of study registration. * Laboratory values must be within protocol specified ranges. * Females of childbearing potential must have a negative pregnancy test. * Females of childbearing potential and males must use an effective method of contraception from the time of consent until at least 365 days following discontinuation of protocol therapy. Exclusion Criteria: * Patient must not have obvious clinical progression of lymphoma after PBSCT as determined by the treating physician. * Cannot be positive for hepatitis B surface antigen, hepatitis B core antibody or HIV antibody. * No major or uncontrolled comorbid conditions as determined by the treating physician: history of ventricular arrhythmias requiring drug or device therapy; uncontrolled angina or symptomatic congestive heart failure; • severe or uncontrolled infection requiring systemic antibiotic or antifungal therapy or active hepatitis C infection; severe or uncontrolled psychiatric illness. * No known leptomeningeal involvement by lymphoma or current metastatic brain disease. * No Corrected QTc interval \> 480 msec. * No known or suspected hypersensitivity to ofatumumab or SB-485232 that in the opinion of the investigator is a contraindication to their participation in the study. * No systemic (oral or parenteral) corticosteroids within 14 days of study entry. * Not receiving concurrent chemotherapy, biologic therapy, radiotherapy, or other investigational therapy. * No previous treatment with SB-485232 or ofatumumab. * No history of other malignancy except for adequately treated non-invasive cancers of the skin (basal or squamous cell) or carcinoma in situ of the uterine cervix. * No diabetes mellitus with poor glycemic control (documented hemoglobin A1c \>7% within 4 weeks prior to study entry).