To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients

Inclusion Criteria: * Patients ≥40 and ≤ 80years of age * Radiographic evidence of grade 2 or 3 osteoarthritis based on the Kellgren \& Lawrene radiographic entry criteria * Stable osteoarthritis during 3 months * Score of 100mm pain VAS ≤ 80mm at screening * Score of 100mm pain VAS ≥ 50mm at baseline * Written consent form voluntarily Exclusion Criteria: * Disease of spine or other Lower limb joints that could affect to evaluate the efficacy * History of surgery or arthroscopy of the study joint within 6 months * Trauma of study joint within 12 months * Medication of constantly(more than 1 week) corticosteroid by oral within 3 months * Medication of intra-articular injection within 3 months * Diagnosed with psychical disorder, and taking medication * History of upper gastrointestinal ulceration within 6 months * History of upper gastrointestinal bleeding within 12 months * Serum creatinine, ALT, AST, total bilirubin over UNL X 2.0 at screening test * History of hypersensitivity to LAYLA, JOINS, or NSAIDs * Participation in another clinical trials within 4 weeks * Medication of constantly (more than 1 week) narcotic analgesics within 3 months * Not consent about using effectual contraception method during trial * Pregnant or lactating woman * Investigator's judgment