Laparoscopic Versus Open Left Hemihepatectomy for Liver Benign Lesions

Sir Run Run Shaw Hospital60 enrolled

Overview

The purpose of this study is to investigate the influence of the laparoscopic and open left hemihepatectomy on acute surgical trauma and stress response.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Benign Lesions in Left Liver

Interventions

Laparoscopic left hemihepatectomyPROCEDURE

participants will be performed with laparoscopic left hepatectomy using laparoscopic instruments

Open left hemihepatectomyPROCEDURE

participants will be performed with traditional open left hepatectomy using laparotomic instruments

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient with benign lesions who requires left hemihepatectomy * Child-Pugh classification of A to B * American Society Of Anesthesiologists (ASA) grading of I to III * a body mass index of between 18 and 35 * willingness to participate in the study * able to understand the nature of the study and what will be required of them Exclusion Criteria: * pregnant or lactating women * unwillingness to participate * Child-Pugh classification of C * ASA grading of IV to V * with condition of acute inflammatory,fever or diabetes mellitus * with autoimmune disease or immunodeficiency * taking drugs that affect the immune system

Locations (1)

Department of General Surgery, Institute of Minimally Invasive Surgery, Sir Run Run Shaw Hospital

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

Plasma C-reactive protein (CRP) level

CRP will be tested before operation, 3,12,24 hours and 3,5,7 days after operation

Time frame: up to 7 days

Secondary Outcomes

Inflammatory response markers including interleukin-6, interleukin-10 concentrations and tumor necrosis factor α level in serum

interleukin-6 and interleukin-10 will be tested before operation, 3,12,24 hours and 3,5,7 days after operation

Time frame: up to 7 days

Oxidative stress status including plasma malondialdehyde level and total antioxidant capacity

plasma malondialdehyde level and total antioxidant capacity will be tested before operation, 3,12,24 hours and 3,5,7 days after operation

Time frame: up to 7 days

Immune status including white blood cell count and human leukocyte antigen DR (HLA-DR) expression

white blood cell count and human leukocyte antigen DR (HLA-DR) expression will be tested before operation, 3,12,24 hours and 3,5,7 days after operation

Time frame: up to 7 days

Status of insulin resistant

Status of insulin resistant will be tested before operation, 3,12,24 hours and 3,5,7 days after operation

Time frame: up to 7 days

Systemic inflammatory response syndrome

Time frame: up to 7 days

Status of hepatic cell apoptosis including hematoxylin and eosin (HE) staining, immunohistochemistry staining and caspase-3 expression

Time frame: 24 hours

Data from ClinicalTrials.gov

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