Effects of L-carnitine on Hypothyroidism

Korea University Anam Hospital60 enrolled

Overview

L-carnitine and thyroid hormone tended to antagonize reciprocally in human body. Urinary excretion of L-carnitine decreased in hypothyroid patients, and levothyroxine supplementation increased excretion of L-carnitine. The investigators hypothesized that supplying L-carnitine to hypothyroid patients with fatigue symptom could improve the quality of life, and fatigue score in them. Therefore, the investigators planned to compare the efficacy of L-carnitine and placebo in hypothyroid patients who had taken levothyroxine.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Hypothyroidism

Interventions

L-carnitineDRUG

PlaceboDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Clinical diagnosis of hypothyroidism with fatigue symptom * Currently use of the same amount of levothyroxine over at least six months * Normal serum free T4 level Exclusion Criteria: * Current smoker * Serum hemoglobin level of under 12mg/dL * Clinical diagnosis of diabetes mellitus or fasting serum glucose level ≥ 126mg/dL or HbA1c level ≥ 6.5% * History of significant heart failure * History of large amount of alcohol consumption * Uncontrolled hypertension (systolic blood pressure ≥ 160 millimeter of mercury (mmHg) or diastolic blood pressure ≥ 100 mmHg * pregnant, or planning to be pregnant, or breast feeding women * aspartate aminotransferase (AST) or alanine aminotransferase (ALT) ≥ 2 times of normal limit * serum Cr level \> 2.0mg/dL

Locations (1)

Korea University Anam Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Fatigue Severity scale

Change from Baseline in Fatigue severity scale at 12 weeks (scoring 'fatigue severity scale' at baseline and 12 weeks)

Time frame: baseline and 12 weeks

Secondary Outcomes

Wessely and Powell score

Change from Baseline in Wessely and Powell score at 12 weeks (scoring 'Wessely and Powell score' at baseline and 12 weeks)

Time frame: baseline and 12 weeks

Data from ClinicalTrials.gov

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