This study has 2 parts. Each participant will receive a daily injection of LY2605541 during one treatment period and a daily injection of insulin glargine during one treatment period. Each treatment period is 2 to 3 weeks and is followed by a procedure to lower blood sugar levels to see how the body recovers after each treatment.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
25
For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.
Neuss, Germany
Concentration of Epinephrine
Epinephrine levels are presented. Each participant's measurements at 30, 15, and 0 minutes preclamp on the day of the clamp were averaged for the baseline value, and measurements at blood glucose (BG) level attainment and +10, 20, and 30 minutes were averaged for the BG nadir value.
Time frame: 30, 15, and 0 minutes Preclamp; 10, 20, and 30 minutes Post-Clamp
Amount of Glucose Required to Reach Blood Glucose (BG) of 72 mg/dL
The amount of infused glucose required to reach BG of 72 milligrams per deciliter (mg/dL) is presented.
Time frame: 30, 15, and 0 minutes Preclamp; 10, 20, and 30 minutes Post-Clamp
Amount of Glucose Required to Maintain BG of 72 mg/dL
The amount of infused glucose required to maintain BG of 72 mg/dL for 1 hour is presented.
Time frame: 30, 15, and 0 minutes Preclamp; 10, 20, and 30 minutes Post-Clamp
Concentration of Cortisol
Cortisol levels are presented. Each participant's measurements at 30, 15, and 0 minutes preclamp on the day of the clamp were averaged for the baseline value, and measurements at BG level attainment and +30 minutes were averaged for the BG nadir value.
Time frame: 30, 15, and 0 minutes Preclamp; 10, 20, and 30 minutes Post-Clamp
Concentration of Glucagon
Glucagon levels are presented. Each participant's measurements at 30, 15, and 0 minutes preclamp on the day of the clamp were averaged for the baseline value, and measurements at BG level attainment and +30 minutes were averaged for the BG nadir value.
Time frame: 30, 15, and 0 minutes Preclamp; 10, 20, and 30 minutes Post-Clamp
Concentration of Growth Hormone
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Growth hormone levels are presented. Each participant's measurements at 30, 15, and 0 minutes preclamp on the day of the clamp were averaged for the baseline value, and measurements at BG level attainment and +30 minutes were averaged for the BG nadir value.
Time frame: 30, 15, and 0 minutes Preclamp; 10, 20, and 30 minutes Post-Clamp
Concentration of Norepinephrine
Norepinephrine values are presented. Each participant's measurements at 30, 15, and 0 minutes preclamp on the day of the clamp were averaged for the baseline value, and measurements at BG level attainment and +10, 20, and 30 minutes were averaged for the BG nadir value.
Time frame: 30, 15, and 0 minutes Preclamp; 10, 20, and 30 minutes Post-Clamp