Huaier Granule for Prevention of Recurrence and Metastasis of Hepatocarcinoma After Radical Hepatectomy

Inclusion Criteria: * Age: ≥ 18 and ≤ 75 years, both male and female; * Radical hepatectomy has been performed for hepatocellular carcinoma; * The hepatocellular carcinoma has been confirmed by pathological examination; * Barcelona clinic liver cancer(BCLC) stage A or B; * Not receiving any preoperative anticancer drug; * The liver and kidney function satisfies the following conditions within 15 days after surgery (excluding day 15): aspartate aminotransferase(AST), glutamic-oxalacetic transaminase(ALT)\<3 upper limit of normal(ULN), total bilirubin≤2ULN, serum creatinine \<1.5 ULN; * Other laboratory tests meet the following requirements within 15 days after surgery (excluding day 15): Hb≥9g/dl, platelet count≥60×109/L, absolute neutrophil count\>1.0×109/L; * The expected survival time ≥ 12 weeks; * The subjects volunteer to sign the informed consent. Exclusion Criteria: * Hepatocellular carcinoma patients who received non-radical hepatectomy; * Non-hepatocellular carcinoma patients; * Those with Child-Pugh C; * Pregnant or lactating women; * Those with active bleeding due to various reasons; * Those with HIV infection or AIDS-associated diseases; * Those with severe acute and chronic diseases; * Those with severe diabetes; * Those with serious infectious diseases; * Those who can not take drugs by oral route; * Drug abusers or those with psychological or mental diseases that may interfere with study compliance; * Conditions that are considered not suitable for this study investigators