The purpose of this study is to investigate if nitazoxanide used in combination with interferon alfa and ribavirin is effective in treating Hepatitis c infected type 2 Diabetic patients by improving their sustained viral response by more than 80%.Considering that the study is being conducted in a third world country like Pakistan, the standard treatment of hepatitis C is not cost effective. The aim is to introduce a new treatment comparable in efficacy to peginterferon and also cost effective.
After taking proper informed consent from patients, patients who fulfill the research criteria are randomized into 2 groups (control/study). Patients in both groups will be treated with conventional interferon alfa and Ribavirin.Those in study group will be given tab nitazoxanide 500mg twice daily in addition to conventional treatment. The patients will be followed up at regular intervals: 0,4,12,24,48 week.At each visit Hepatitis C Virus(PCR)RNA, Liver function tests, complete blood count will be done.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
66
nitazoxanide 500mg twice daily
Inj interferon 3 Million International Units thrice weekly
ribazole
Endocrinology and Diabetes management centre
Lahore, Punjab Province, Pakistan
Sustained Viral Response,
Sustained viral response ,is negative Hepatitis C Virus(PCR)RNA test six months after end of treatment.
Time frame: 48 WEEK
Normalization of Alanine Transferase Test
Liver function test,showing resolution of the inflammation of liver parenchyma
Time frame: 48week
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