A Phase II Trial of Genexol-PM and Gemcitabine in Patients With Advanced Non-small-cell Lung Cancer

Inclusion Criteria: * age over 18 * histologically or cytologically confirmted non-small cell lung cancer * stage IIIb with pleural effusion or stage IV * ECOG PS 0-2 * at least one measurable lesion * expected life span more than 3 months * normal bone marrow, liver, renal function * no prior chemotherapy or radiotherapy except for whole brain radiotherapy for symptomatic brain metastases * more than 6 months from the last adjuvant chemotherapy Exclusion Criteria: * active infection * severe comorbitidies * pregnant or lactating women * other invasive malignancies * poorly controlled symptomatic brain metastases