CPAP and Nebivolol in Hypertensive Obstructive Sleep Apnea (OSA) Patients.

Inclusion Criteria: * male/female ≥ 18 years old * patient with obstructive sleep apnea (apnea-hypopnea index ≥ 20) naïve for CPAP treatment * patient with weak or moderate hypertension (140 \<= systolic blood pressure (SBP) \< 180 mmHg and 90 \<= diastolic blood pressure (DBP) \< 110 mmHg naïve for any antihypertensive treatment * negative pregnancy test * ambulatory patient * patient who have signed the informed consent form * patient affiliated to social security Exclusion Criteria: * pregnant or nursing woman * acute hepatic failure, biliary cirrhosis, cholestasis * clearance of Cockcroft \< 30 ml/min/1.73m2 * sick sinus syndrome, including sino-atrial block * second and third degree heart block (without a pacemaker) * history of bronchospasm and bronchial asthma * bradycardia (heart rate\< 60bpm prior to start therapy) * severe peripheral circulatory disturbances * acute hypertension (SBP\>= 180 mmHg and/or DBP \>= 110 mmHg) * severe daytime sleepiness (Epworth rating scale \> 15) * known cardiovascular pathologies * contraindication to CPAP * allergy to nebivolol * patient treated with antihypertensive drug(s), with class I antiarrhythmics (quinidine, hydroquinidine, cibenzoline, flecainide, disopyramide, lidocaine, mexiletine, propafenone) * patient treated with CPAP * patient kept in detention, major protected by the law, hospitalised person * patient currently participating in another clinical trial