Glucotoxicity and Acute Exercise

Rigshospitalet, Denmark

Overview

Experimental hyperglycemia (5 hours) will be induced via a constant- or fluctuating-rate glucose infusion to establish different patterns of glycemia in healthy individuals. The effects of these acute models of hyperglycemia on the adaptations to a single aerobic exercise bout will be tested. Changes in pancreatic endocrine function, insulin sensitivity, endothelial function, and oxidative stress will be measured.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Conditions

Type 1 Diabetes Type 2 Diabetes

Interventions

ExerciseBEHAVIORAL

HyperglycemiaPROCEDURE

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion criteria for participation: * Male * Age 18-50 years * Body Mass Index 19-30 kg/m2 * Generally healthy Exclusion criteria for participation: * Regular use of anti-inflammatory medication * Smokers * More than 2 kg weight change in prior 6 months * Previous weight loss surgery * Cancer, or evidence of chronic haematological, pulmonary, cardiac, hepatic, renal, or gastrointestinal disease * Evidence of diabetes * Engaged in moderate or vigorous activity on more than 5 days per week

Locations (1)

University of Birmingham

Birmingham, West Midlands, United Kingdom

Outcomes

Primary Outcomes

Pancreatic endocrine function

The plasma insulin, C-peptide, and glucagon responses to a 0.33 g/kg intravenous glucose tolerance test (IVGTT) will be measured. In each trial, the IVGTT will be performed at T = 0, 6, 7, 9, and 24 hours.

Time frame: 0, 6, 7, 9, and 24 hours

Secondary Outcomes

Glucose tolerance

Glucose tolerance will be measured during an IVGTT in each trial at T = 0, 6, 7, 9, and 24 hours.

Time frame: 0, 6, 7, 9, and 24 hours

Endothelial function

Blood flow and flow-mediated dilation by Doppler ultrasound will be measured in each trial at T = 0, 6, 7, 9, and 24 hours.

Time frame: 0, 6, 7, 9, and 24 hours

Oxidative stress

Urine will be collected over the whole 24-hour period of each trial and 8-iso Prostaglandin F3α will be measured.

Time frame: 24 hours

Data from ClinicalTrials.gov

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