Comparison of Two Triple Regimens for Treatment and Retreatment of Chronic Hepatitis C Infection

Inclusion Criteria: * Age - 18-64 years * HCV genotype 1 * HCV RNA \>100,000 * Liver biopsy within 5 years before enrollment * Absolute neutrophil count of at least 1200 per cubic millimeter * Platelet count of at least 90,000 per cubic millimeter * Hemoglobin level of at least 12 g per deciliter * Signed informed consent and Health Insurance Portability and Accountability Act (HIPAA) forms Exclusion Criteria: * HCV genotypes other than genotype 1 * Immunocompromised conditions including HIV, transplant or immunosuppressive drugs * Decompensated liver disease or hepatocellular carcinoma * Any other types of active cancer * Active autoimmune disorders * Major psychiatric disorders * Active drug or alcohol use * Pregnancy or lactation * Patients with allergy to any of the drugs used in this study * Drugs that may interact with boceprevir or telaprevir as listed in the package insert