Measurement of Retinal Venous Pressure Under Short-term Low-oxygen Environment

University Hospital, Basel, Switzerland24 enrolled

Overview

The hypothesis is that the pressure in the retinal veins increases under a short-term lack of oxygen and leads to a decreased blood circulation. On the basis of measurements in the hypobaric chamber this hypothesis should be verified.

Conduct a pilot study to describe and quantify the retinal venous pressure (RVP) in healthy volunteers under conditions of controlled, reduced ambient and oxygen partial pressure in the pressure chamber of the Aeromedical Institute FAI in Dübendorf, Switzerland. Obtaining evidence of the adaptation behavior of the retinal vascular system in controlled, short-term hypoxic changes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Healthy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy Exclusion Criteria: * eye diseases * systemic diseases * term medication (except contraceptives) * pregnancy * allergies to the ingredients Alcain, Tropicamide and Phenylephrine * blood pressure levels except standard (\<60 /\> 140 mmHg) * oxygen saturation (SO2) \<90%

Locations (1)

University of Basel, Dept. of Ophthalmology

Basel, Switzerland

Outcomes

Primary Outcomes

Retinal venous pressure

Quantify the changes in the retinal venous pressure (RVP)

Time frame: 1 hour

Data from ClinicalTrials.gov

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