The purpose of this randomized, controlled, cross over single meal study is to investigate the metabolic effects of a breakfast rich in dairy proteins and to determine biomarkers for their intake. The results from this project will increase our knowledge about nutritional value of dairy proteins, which is necessary to decide whether dairy products can be recommended for prevention of weight related bone loss.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
17
Test meals with different protein types (dairy versus meat)
Department of Human Nutrition, University of Copenhagen
Copenhagen, Frederiksberg C, Denmark
serum C-terminal carboxy-terminal collagen crosslinks (CTX)
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
urine C-terminal carboxy-terminal collagen
Time frame: baseline 24-h urine samples and 24-h urine samples after the meal test at both visits
serum osteocalcin (sOC)
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
serum tartrate-resistant acid phosphatase (s-TRAP)
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
urine deoxypyridinoline crosslink (uDPD)
Time frame: baseline 24-h urine samples and 24-h urine samples after the meal test at both visits
plasma metabolites for metabolomics analyses
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
urine metabolites for metabolomics analyses
Time frame: baseline 24-h urine samples, 24-h urine samples after the meal test, urine samples at 2-h and 4-h after the meal test and urine samples from 4-h to 24-h, all at both visits
serum insulin-growth factor-1 (IGF-1)
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
serum insulin-growth factor binding-protein-3 (IGFBP-3)
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
serum insulin
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Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
serum glucose
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
serum glukagon-like peptide-1 (GLP-1)
Time frame: at 0, 30, 60, 120, 180 and 240 min at both visits
urinary PABA
Time frame: baseline 24-h urine samples and 24-h urine samples after the meal test at both visits
urinary creatinin
Time frame: baseline 24-h urine samples and 24-h urine samples after the meal test at both visits
urinary biobank
Time frame: baseline 24-h urine samples and 24-h urine samples after the meal test at both visits
plasma biobank
Time frame: at 0, 30, 60, 90, 120, 180 and 240 min at both visits