Blastocyst Culture Using Time-lapse in Good Prognosis IVF Patients and Elective Single Embryo Transfer

Dr. Murat Çetinkaya64 enrolled

Overview

Choosing the best embryo for transfer has become the major challenge in in vitro fertilization (IVF). Morphology alone is obviously not enough and time-lapse incubation has added embryo development kinetics as another selection criterion. This study was designed to select for the top blastocyst to be replaced, while increasing the pregnancy chance, with the local legislation regulating the number of embryos to be transferred and to establish a morphokinetic standard to be used in our clinical setting.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Masking

NONE

Enrollment

Conditions

Infertility

Interventions

EmbryoscopeDEVICE

Five-day embryo culture in embryoscope which is an incubator with a built-in camera

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients in their first or second ART treatment cycle * no recurrent spontaneous abortions * age\<35 years * BMI\<28 kg/m2 * ≥8 oocytes retrieved Exclusion Criteria: * severe endometriosis * polycystic ovary syndrome * hydrosalpynx * uterine pathology * severe male factor (presenting less than 5 million motile sperm cells in total in the ejaculate) * very severe morphological sperm defects (mainly globozoospermic or macrocephalic samples)

Locations (1)

Sisli Memorial Hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Blastocyst formation rate

Time frame: 5th day of embryonic development

Secondary Outcomes

Clinical pregnancy rate

Clinical pregnancy was defined as the presence of a gestational sac detected on ultrasound 3 weeks after the first βhCG test, which was performed 14 days after oocyte retrieval.

Time frame: 7th week of pregnancy

Data from ClinicalTrials.gov

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