Comparison of Individual Culture and Group Culture of Preimplantation Embryos in Human IVF Treatments

Semmelweis University532 enrolled

Overview

Prospective randomized comparison of two widely used in vitro culture system in human IVF treatments. In vitro fertilized oocytes and embryos are cultured in individual culture media droplets using conventional petridish or in group culture using WOW (well of the well) petridish. Primary outcome: implantation and pregnancy rates Secondary outcome: fertilization rate and embryo quality

Study Type

OBSERVATIONAL

Enrollment

532

Conditions

Other Complications Associated With Artificial Fertilization

Interventions

individual embryo culture or group cultureOTHER

Embryos cultured in a 25 microliter droplet of culture media individually in a conventional petridish or in groups of 2-10 embryos in a Well-of-the-Well petridish

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Infertile patients entering in vitro fertilization treatment * at least 1 oocyte collected Exclusion Criteria: * no oocytes collected

Locations (1)

Semmelweis University First Department of Obstetrics and Gynecology

Budapest, Hungary

Outcomes

Primary Outcomes

Clinical pregnancy rate

Number of clinical pregnancies (/No. of embryo transfers)

Time frame: 4 weeks after the embryo transfer

Implantation rate

Number of embryos implanted (/number of embryos transferred)

Time frame: 4 weeks after embryo transfer

Secondary Outcomes

Fertilization rate

Number of oocytes fertilized. (only in intracytoplasmic sperm injection cycles)

Time frame: 18 hours after sperm injection

Embryo quality

Number and quality of blastomeres, amount of fragmentation embryo grade

Time frame: 36 and 72 hours after fertilization

Data from ClinicalTrials.gov

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