Insulin Sensitivity and Beta Cell Function After Carbohydrate Loading in Hip Replacement Surgery

Karolinska Institutet23 enrolled

Overview

The purpose of this study is to determine whether preload of carbohydrate or water before elective hip replacement improve insulin sensitivity and or beta cell function in human.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Insulin Sensitivity

Interventions

Experimental: PreOp, NutriciaNordica ABDIETARY_SUPPLEMENT

Placebo Comparator: WaterDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Elective hip replacement Exclusion Criteria: * Known diabetes mellitus * Kidney failure (creatinine clearance \<40 ml/min * Liver failure (aspartate and alanine aminotransferases x 2 above reference) * Hb \<110 g/l * Ongoing severe bacterial or viral infection * Malignancies * Psychiatric disease

Locations (2)

Södersjukhuset AB

Stockholm, Sweden, Sweden

Södertälje hospital

Södertälje, Södertälje, Sweden

Outcomes

Primary Outcomes

Change in Insulin Sensitivity

Insulin sensitivity is measured by euglycemic hyperinsulinemic clamp

Time frame: Morning before surgery and up to two days after surgery

Secondary Outcomes

Change in Beta Cell Function

Beta cell function is measured with intravenous glucose tolerance test (IVGTT)

Time frame: Morning before surgery and up to two days after surgery

Data from ClinicalTrials.gov

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