Use Of Three Commercial Preparations Of Injectable Hyaluronic Acid In Hands Rejuvenation

Inclusion Criteria: * Subjects agreeing to take part of all procedures of the study (including pre-test, filler injection, photographs, etc.), after being fully informed on the objectives and nature of the investigations; * Written Informed Consent; * Treatment-naive patients for fillers in hands; * Subjects of both genders over 18 years; * Fitzpatrick skin phototypes I to VI; * Subjects presenting a similar loss of fatty tissue on both hands, at least of 2 according the Validated Hand Grading Scale2; * Medical history and physical examination which, based on the investigator's opinion, do not prevent the patient from taking part in the study and use the product under investigation; * Female subjects of childbearing age should present a negative urine pregnancy test and should be using an effective contraceptive method; * Availability of the subject throughout the duration of the study (208 days); * Subjects with sufficient schooling and awareness to enable them to cooperate to the degree required by this protocol. Exclusion Criteria: * Pregnant women or women intending to become pregnant in the next 18 months; * Subjects with known hypersensitivity to any hyaluronic acid products; * Subjects with history of adverse effects, such as sensitivity to the components of the formula, or any other adverse effect, which in the investigator's opinion should prevent the patient from participating in the study; * Subjects participating in other clinical trials; * Any prior surgery or side effects at the hands area, or any prior cosmetic procedures, including permanent fillers, that may interfere with the results; * Subjects with active inflammation or infection in the area to be treated; * Subjects with a history of medical treatment non-adherence or showing unwillingness to adhere to the study protocol; * Subjects presenting diseases such as coagulation disorders or under the use of anticoagulants, or any condition that, in the opinion of the investigator, can compromise the evaluation of the study.