Phase 1 SAD and MAD Study of NGM282 in Healthy Adult Participants

Inclusion Criteria: * Males or females, between 18 and 65 years of age, inclusive * BMI range is 20-35 kg/m2, inclusive for the SAD Module, and 25-35 kg/m2, inclusive for the MAD Module at Screening; * In good health, determined by no clinically significant findings from medical history, physical exam, 12 lead ECG, clinical laboratory findings, and vital signs at Screening and Day -1 Exclusion Criteria: * Significant history or clinical manifestation of any significant metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, GI, neurological, or psychiatric disorder (as determined by the PI) * History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance