The purpose of this project is to determine during moderate rise of intracranial pressure (ICP) in awake patient, the change in autonomic function and its influence on cerebral and systemic haemodynamics.
From preliminary data, we know that changes in ICP influences both systemic and cerebral haemodynamics, introducing the concept of intracranial baroreflex We have to i) confirm the presence of this intracranial baroreflex, ii) analyze the changes in autonomic function during moderate rise in intracranial pressure (ICP) in human, and iii) correlate the changes in cerebral and systemic haemodynamics with autonomic function.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
10
Infusion studies are performed in daily clinical routine to measure cerebrospinal fluid resistance outflow. During this test ICP is slowly and securely raised. Investigators plan to analyze what are the consequences of this ICP rise in terms of autonomic system and hemodynamics.
University Hospital of Toulouse
Toulouse, France, France
University Hospital Toulouse
Toulouse, France
University Hospital
Toulouse, France
change in sympathetic nerve activity after rise in ICP
Assessment of autonomic neural function using. 1. microneurography to assess the muscle sympathetic nerve activity 2. measurement of the plasma level changes of noradrenaline 3. power spectral analysis of heart rate and arterial blood pressure
Time frame: within few minutes
change in hemodynamics after rise in ICP
Assessment of haemodynamics 1. Cerebral haemodynamics. using Transcranial doppler 2. Systemic haemodynamics measured with photoplethysmography
Time frame: within few minutes
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