Comparison of Standard Versus Low Bicarbonate Hemodialysis

Albert Einstein College of Medicine10 enrolled

Overview

This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate concentration in a patient's blood with that in the dialysate.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Kidney Disease Metabolic Acidosis

Interventions

Low bicarbonate dialysisOTHER

Eligibility

Sex: ALLMin age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months * Age \> 18 years Exclusion Criteria: * Use of oral alkali within the previous month * Hospitalization within the previous month * Inability to provide written informed consent * Pregnancy

Locations (1)

Montefiore Medical Center/Jack D. Weiler Hospital

The Bronx, New York, United States

Outcomes

Primary Outcomes

Change in beta-hydroxybutyrate clearance

Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations

Time frame: 1-2 weeks

Change in lactate clearance

Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations

Time frame: 1-2 weeks

Post-dialysis pH

Time frame: 1-2 weeks

Post-dialysis bicarbonate

Time frame: 1-2 weeks

Data from ClinicalTrials.gov

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