The Role of Mid-Life Adiposity in Functional Brain Connectivity

Medical College of Wisconsin60 enrolled

Overview

The purpose of the study is to use functional MRI (fMRI) to measure brain connectivity in middle-aged individuals with different levels of body fat. The ultimate goal of this research is to develop an early diagnostic tool for Alzheimer's disease.

Participants will have one visit for: * Blood draw * Body composition scan * Cognitive screen * Neurological exam * MRI scan The visit will take approximately 3 hours.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Alzheimer's Disease

Eligibility

Sex: ALLMin age: 45 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 45-65 years of age * Normal memory * Right-handed * General good physical health Exclusion Criteria: * History of stroke or neurological disease * Seizures or head injury with loss of consciousness within the last five years * Ferrous (magnetic) or electronic implants (due to the magnet in the MRI scanner) * Claustrophobia More detailed inclusion/exclusion criteria must be met in order to qualify for the study. The study coordinator will determine eligibility.

Locations (1)

Medical College of Wisconsin/Froedtert Hospital

Milwaukee, Wisconsin, United States

Outcomes

Primary Outcomes

Brain connectivity measured by fMRI

Time frame: One visit

Data from ClinicalTrials.gov

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