Modafinil for Smoked Cocaine Self-Administration

Inclusion Criteria: 1. Smokes cocaine 2. Has patterns of smoked cocaine use in terms of frequency and amount which parallel or exceed those administered in the study. 3. Age 21-50. 4. Able to give informed consent, and comply with study procedures. 5. Normal body weight Within normal weight range (for appropriate frame) according to 1983 Metropolitan Weight tables - Exclusion Criteria: 1. Current seizure disorder, heart disease or a history of serious adverse effects due to cocaine. 2. Dependence on substances (other than cocaine or nicotine) or a history of dependence on alcohol 3. Request for drug treatment 4. Judged to be noncompliant with study protocol. 5. Current use of any psychotropic medication. 6. Clinical laboratory tests outside normal limits that are clinically unacceptable to the study physician (BP \> 140/90; BUN, creatinine, LFTs \> 3x ULN; hematocrit \< 34 for women, \< 36 for men; pseudocholinesterase deficiency) 7. History of myocardial infarction or ischemia, clinically significant left ventricular hypertrophy, angina, clinically significant arrhythmia, or mitral valve prolapse 8. Currently meeting DSM-IV criteria for all major psychiatric/psychotic disorders other than transient psychosis due to drug abuse 9. Current parole or probation Self-report during interview -