Despite the prevalence of osteopenia and osteoporosis in the HIV positive population, relatively little is known about the underlying pathology. This prospective cohort study aims to gain further understanding about a number of issues relating to low bone mineral density in HIV-infected subjects.
This study will follow HIV positive and negative subjects annually for 5 years. The aims of this study include: * to describe the pathology underlying low bone mineral density * to assess the relationship between low bone mineral density and antiretroviral therapy exposure * to assess the relationship between low bone mineral density and vitamin D /PTH status and/or markers of bone metabolism * to assess the relationship between osteopenia and subsequent changes in bone mineral density and markers of bone metabolism * to assess the validity of the currently available fracture risk assessment tool in predicting fractures in HIV positive populations
Study Type
OBSERVATIONAL
Enrollment
500
Mater Misericordiae University Hospital
Dublin, Ireland
RECRUITINGBone pathology
To describe abnormalities in bone pathology in bone biopsies from HIV-infected subjects with low bone mineral density by comparing biopsy indices to reference ranges.
Time frame: 3 years
Rates of change in bone mineral density
To determine rates of change in bone mineral density in HIV-positive patients compared to HIV-negative controls
Time frame: 3 years
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