Aspirin-Exacerbated Respiratory Disease, or AERD, consists of aspirin sensitivity, asthma and nasal polyps. It is currently managed by chronic steroid use, multiple endoscopic sinus surgeries and/or aspirin desensitization. However, these treatments have potential adverse effects. A theory has been postulated that decreasing the level of dietary salicylates may help in long-term control of disease. A current trial is in the works to evaluate the clinical outcomes of decreased salicylate, but measurements of biochemical markers of disease has not yet been done. The hypothesis is that decreased dietary salicylates will result in a decrease in urinary salicylates and inflammatory markers of disease, cys-leukotrienes, which are typically elevated in this disease.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
7
Participants followed a 7 days period under a Low salicylate diet
Participants followed a 7 days period under a Normal Diet
St. Joseph's Health Care
London, Ontario, Canada
Urinary Levels of Cys-Leukotrienes
Time frame: 14 days after commencement
Urinary Salicyluric Acid Levels
Time frame: 14 days after commencement
Urinary Salicylic Acid Levels
Time frame: 14 days after enrollment
Urinary Creatinine Levels
Time frame: 14 days after commencement
Sino-Nasal Outcome Test (SNOT-22)
The Sino-Nasal Outcome Test (SNOT-22) is a validated 22-item Chronic rhinosinusitis-specific instrument which is scored using a scale where 0="No problem", 1="Very mild problem", 2="Mild or slight problem", 3="Moderate problem", 4="Severe problem", and 5="Problem as bad as it can be". Higher scores on the SNOT-22 survey items suggest worse patient functioning or symptom severity (total score range: 0-110)
Time frame: 14 days after commencement
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.